NeuroScience, Inc. is an authorized provider for MELISA® testing in the USA!When previous test results and/or patient history indicate the presence of inflammation, further testing might be warranted to identify the root cause. MELISA® is the premier test for identifying physical stressors that can cause Type IV hypersensitivity reactions, which may lead to inflammation and chronic disease.
What is MELISA®?
MELISA® is a MEmory Lymphocyte Immuno-Stimulation Assay. MELISA® measures Type-IV delayed hypersensitivity reaction to foreign materials (antigens and pathogens). A Type-IV hypersensitivity reaction is mediated by memory T-lymphocytes that had contact with a given foreign material. The MELISA® test indicates:
- Hypersensitivity to an antigen
- Prior exposure to an antigen
- Potential presence of an antigen
This information can be used to guide interventions for optimal patient outcomes.
It is Important to Differentiate Between Hypersensitivity and ToxicityMELISA® provides a measurement of sensitivity to foreign materials. Patients with hypersensitivities may react to levels below the official "safe limit" reported on tests analyzing excreted levels of metals.
There is no such thing as a "safe limit" for hypersensitive individuals.
How is the MELISA® different from other tests currently sold in the USA?Foreign materials can hide inside cells and modify proteins. These modified proteins may be considered foreign and can activate the immune system, leading to chronic inflammation if the presence of the material is not addressed. Current methods of analysis detect only excreted foreign materials in your hair, fingernails, urine, or serum. They do not detect the hidden stores within cells. Therefore, analysis based upon excreted levels may be inappropriate.
How is the test performed?The test procedure uses white blood cells (lymphocytes) from whole blood specimens, which are isolated and tested against the foreign materials chosen. If a patient has been previously exposed to a foreign material, MELISA® test results will confirm whether the patient is hypersensitive to that particular foreign material. MELISA® may also detect if the foreign material is still present in the body. People who are hypersensitive and have the presence of that particular foreign material/antigen in their bodies will have an ongoing immune response to these materials, which can lead to chronic inflammation.
- MELISA® Testing Profiles: Metals I, Metals II, Amalgam/Dental, Dental Expanded, Metal Implants, Metals Pain/Fatigue, Mercury
- MELISA® Metal Biographies
- White Paper - Hypersensitivity
- Validity of MELISA® Testing
- LTT MELISA® Clinical Relevance
Links to websites with information about sources of toxins and metals used in products:
- Which Medical Device, a review and information site about medical devices that includes information about metals used in orthopedic and cardiology implants, with brand names.
- FDA medical device approval information - implanted device component information available (use the search field on the web page and enter the name of the device)
- Environmental working group "skin deep" database of metals used in cosmetics and toiletries
- FDA information on metals used in drugs and pharmaceuticals
- The Ecology Center website healthystuff.org database of metals used in children's products, toys, pet products, cards, apparel, and accessories
- U.S. Environmental Protection Agency (EPA) information about sources of mercury exposure
- U.S. National Institutes of Health (NIH) information on sources of mercury
- U.S. food and drug administration code of federal regulations for cosmetics